Analytical X-ray Techniques in Pharmaceutical Industry

Structural characterization methods are essential tools at all stages of pharmaceutical product life cycles. Analytical X-ray techniques particularly well suited to drug development include Single Crystal X-Ray Diffraction (SC-XRD), X-Ray Powder Diffraction (XRPD), and X-Ray Microscopy (XRM).

SC-XRD plays a crucial role in the establishment of new drug targets and drives structure-based drug discovery, Active Pharmaceutical Ingredient (API) synthesis, and registration of Investigational New Drugs (INDs). Bruker’s state-of-the-art systems enable faster, simpler, and more accessible experiments, allowing researchers in drug development to deliver the right answer quickly.

From a bulk perspective, XRPD finds use in a variety of applications from rapid high-throughput screening for solvates, salts, and co-crystal forms, to stability and aging studies under non-ambient conditions. XRPD also provides insights into degree of crystallinity in Spray Dried Dispersions (SDDs) as well as verification of desired polymorphs in both raw and formulated materials.

XRM and Computed Tomography (XRCT) reveal microstructural information about finished products, including tablets, capsules, and medical devices. This information can be used to understand coating thickness, tablet friability, and distribution of API within oral dosage forms. Learn more.

PHOTON IV – Fourth-Generation CMOS Detector for D8 QUEST and D8 VENTURE

Detailed insight into the relationship between molecular structure, function, and reactivity is crucial for the success of modern science. Crystallography is one of the most powerful methods for generating this vital information and has thus become an essential tool for new discovery in chemistry, biology, pharmacology, mineralogy, and physics. Advancements in software and hardware have enabled researchers to routinely investigate more challenging samples. In addition to accurate goniometers and high-intensity analytical X-ray sources, having a detector that closely approaches theoretical performance is crucial.

At ECM 34 in Padua, we launched the new PHOTON IV detector. This fourth-generation detector represents a significant milestone in X-ray detector technology. It is the choice for researchers and professionals in crystallography who require accurate, precise, and reliable detection of X-ray diffraction signals. The PHOTON IV is available for all D8 QUEST and D8 VENTURE SC-XRD solutions.

The PHOTON IV features a large active area, unprecedented sensitivity, and a high dynamic range, all achieved by utilizing the best scientific-grade CMOS active pixel sensors available. Using proven principles of indirect detection along with a sensor with an ultra-low noise floor, the PHOTON IV elevates X-ray diffraction to a new level of precision and accuracy, all while offering ease of use and reliability

An expanded dynamic range allows for the simultaneous measurement of strong and weak reflections in the same image, largely eliminating the need for repetitive measurements, and leads to a significant increase in data collection efficiency. Harnessing the latest generation sensors, the PHOTON IV provides excellent linearity. Data measured on the PHOTON IV are ultimately accurate, critical for highly demanding applications.

Schedule a demo today!

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Online Seminar: In-House Crystallography – Increasing Efficiency in Drug Discovery and Development

Accelerate discovery, make the right decisions, improve efficiency

Single Crystal X-Ray Diffraction (SC-XRD) plays a crucial role in the establishment of new drug targets and drives structure-based drug discovery, API synthesis, IND registration and new solid form development.

In-house SC-XRD has become substantially faster, simpler and more accessible due to developments in X-ray sources, detectors, crystallographic software and automation.

Modern instruments not only drive research, but their 24/7 accessibility and high uptime mean that they present a highly attractive ROI and can enhance the services provided by CROs.

This online seminar will highlight the capabilities of modern in-house SC-XRD for drug discovery and development and explore the benefits of leveraging the right instrument for different research requirements. We will also consider how a modern SC-XRD facility can provide an attractive ROI and help improve your product quality.

Register now for your preferred time slot!

Register for November 26, 9:00 AM CET (Berlin) / 5:00 PM JST (Tokyo)

Register for November 26, 6:00 PM CET (Berlin) / 9:00 AM PST (San Francisco)

If you cannot attend, feel free to register anyway, and we will send you a link to the recording to watch at your convenience. We look forward to seeing you there!

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Partner Spotlight: Nanotech Scientific at ARABLAB LIVE

Dubai has firmly established itself as a leading hub for businesses, particularly in the Middle East, Africa, and beyond. Bruker AXS, along with other divisions, had the pleasure of participating in ARABLAB LIVE 2024 in Dubai where we conducted several productive meetings with customers and partners.

ARABLAB LIVE 2024   ARABLAB LIVE is the longest-running and largest event for the laboratory and analytical industry in the region, now marking its 43rd year since the start. The show serves as a vital connection point for a wide range of global industries, setting the benchmark for excellence in laboratory practices. It draws participation from a diverse audience, including trade visitors, lab managers, and quality control stakeholders from industries that rely on high-end laboratory equipment and services.

At the event, we were excited to welcome Nanotech Scientific, our new partner based in Islamabad, Pakistan. They are known for their extensive range of analytical equipment and outsourcing solutions, which continue to meet the unique demands of businesses across various sectors. Mr. Wajih Saeed, CEO, and his team bring decades of experience, reliability, and a strong reputation for empowering industries through smart solutions and cutting-edge technology.

The strength of Nanotech Scientific is that they are passionate about work and take pride in their commitment to service. Their goal is to ensure that our customers receive the best possible value for their investment and are satisfied with our products and services by leveraging their vast network of industrial clients, including sectors such as cement, pharmaceuticals, and many more. They strongly believe that their success is linked to the success of clients, and they are committed to supporting them every step of the way.

The show highlighted the continuous advancements in laboratory and analytical X-ray technology and the importance of collaboration between global partners in the field. As the industry evolves, Bruker AXS remains committed to maintaining its role as a key player in driving innovation and supporting businesses with top-tier solutions. Our partnership with Nanotech Scientific positions us to lead in this exciting future. For any inquiry in Pakistan, send email to wajih@nanotechscientific.com or contact them via their website.

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EVENTS

PLASTIC JAPAN 2024
Oct 29 - 31
Tokyo, Japan

Sagamore 2024
Nov 10 - 15
New Delhi, India

Polymer Testing World Expo
Nov 13 - 14
Cleveland, Ohio, USA

SC-XRD User Meeting 2024
Nov 19 - 21
Karlsruhe, Germany

Formnext 2024
Nov 19 - 22
Frankfurt, Germany

NCB Cement & Building Matls
Nov 27 - 29
New Delhi, India

               
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