Analytical X-ray techniques play a pivotal role in advancing the field of pharmaceutical science and industry, offering a range of powerful tools for characterizing and studying various aspects of pharmaceutical compounds and formulations, all along the value chain: from drug discovery to development to manufacturing. Among the notable analytical instruments in this domain, the Bruker AXS SC-XRD (Single Crystal X-Ray Diffraction), XRD (X-Ray Diffraction), XRF (X-Ray Fluorescence), and XRM (X-Ray Microscopy) systems, along with LabScape support solutions, have become indispensable for researchers and professionals in the pharmaceutical sector. These sophisticated instruments enable a comprehensive understanding of pharmaceutical materials, ensuring quality control, structural analysis, and formulation optimization.

Single Crystal X-Ray Diffraction (SC-XRD) has emerged as an invaluable tool for determining the precise atomic arrangement within crystalline pharmaceutical compounds. This technique provides insights into crystal structures, helping researchers understand the three-dimensional arrangement of atoms and molecules. By revealing the arrangement of active pharmaceutical ingredients (APIs) within a crystal lattice, SC-XRD aids in optimizing drug formulation and assessing the stability of pharmaceuticals.

X-Ray Diffraction (XRD) is a widely utilized technique in pharmaceutical science, allowing for the analysis of powdered and crystalline materials. XRD is instrumental in identifying crystalline phases, quantifying amorphous content, and characterizing polymorphs, which is crucial for ensuring the quality, efficacy, and safety of pharmaceutical products. It plays a vital role in batch-to-batch consistency and formulation development, ultimately influencing drug performance.

X-Ray Fluorescence (XRF) spectroscopy offers a non-destructive method for the elemental analysis of pharmaceutical samples. It is a valuable tool for assessing the composition and purity of raw materials, excipients, and finished pharmaceutical products. XRF enables pharmaceutical scientists to verify that products meet regulatory standards and to identify trace contaminants or impurities, which can be critical for patient safety and product quality.

X-Ray Microscopy (XRM) provides a means to investigate the 3D internal structures of pharmaceutical materials at a microscopic scale. This technique is instrumental in studying the morphology, porosity, and distribution of components within drug formulations, including tablets, capsules, and powders. By visualizing microstructural features, XRM helps optimize drug delivery systems and improve the bioavailability of pharmaceuticals.

LabScape support solutions, available exclusively from Bruker, are critical to the pharmaceutical industry, particularly for ensuring maximum uptime and proper maintenance of analytical X-ray equipment. What sets LabScape apart is our factory-trained service engineers who possess in-depth knowledge of these analytical instruments. These skilled professionals facilitate routine maintenance, equipment validation and calibration, remote monitoring, and compliance with regulatory requirements. With LabScape, pharmaceutical professionals can rest assured that their analytical instruments are maintained to the highest standards, ultimately ensuring the safety, efficacy, and quality of pharmaceutical products while streamlining data management and enhancing laboratory efficiency.

We invite you to explore these cutting-edge solutions by visiting Bruker AXS at major pharmaceutical conferences, such as AAPS PharmSci 360, PharmaTech, Interphex, Analytica, and ACHEMA. These events provide an excellent venue to engage with our team, receive live demonstrations, and gain valuable insights into the latest advancements in analytical X-ray technology and services. Bruker is committed to supporting pharmaceutical scientists and professionals in their quest for excellence and innovation in the pharmaceutical industry. We look forward to meeting you and discussing how our solutions can address your specific needs.

Silicone is a widely used release coating material. Silicone coatings offer several desirable performance characteristics for different applications, like improved resistance to slip, moisture, and abrasion. Production of silicone-coated paper, cardboard, and thin film requires a fast and accurate analytical technique for process and quality control. The primary quality requirements for the coated materials are the thickness, purity, stability, and homogeneity of the silicone layer. In this Lab Report, you will learn what our Energy-Dispersive X-Ray Fluorescence (EDXRF) spectrometer, the S2 PUMA Series 2, can do for you.

Residual stress is the localized stress that remains in a material after it has undergone processes such as welding, casting, forming, machining, or thin-film deposition. The analysis of residual stresses is important to understand how these stresses affect the performance and lifetime of a component. Additionally, residual stress can be used to identify specific material properties and failure mechanisms, which can then be used in the design of components and parts. Our new benchtop diffractometer, the D6 PHASER, is uniquely suited for such materials research and characterization. In this application report, we present the capabilities of the system in a reflection diffraction configuration for residual stress analysis of a 200-nm layer of tungsten created by physical vapor deposition (PVD) under Ar atmosphere versus Kr atmosphere.

Hot Isostatic Pressing (HIP) is a process that simultaneously uses high pressure and temperature to improve a material's mechanical properties and workability by reducing the porosity and increasing the density. HIP is applied to many materials, including metal alloys and ceramics. The HIP process is used as a post-printing step for high-quality additive manufactured parts, but also to build a wide variety of components directly, by a near-net-shape powder metallurgic process (PM-HIP). The material produced by PM-HIP is corrosion-resistant and withstands high pressure. This article describes problems that can arise when argon is used as a pressure medium, a new ISO 5842 standard for argon detection, and the G8 GALILEO MS, the only commercially available instrument for measuring argon that's compliant with ISO 5842.

Bruker AXS has established a premium channel partnership with SPECTROMART SCIENTIFIC & LABORATORY EQUIPMENT TRADING LLC, operating in Dubai, UAE, and representing our OES and CS/ONH product lines. The newly established company is owned by three seasoned technocrats, led by Mr. Suyash Nadkarni, along with Mr. Treejan Kurian and Mr. Mukesh Kumar Singh. The trio has combined experience exceeding 50 years in the field of analytical laboratory instruments and scientific equipment. SPECTROMART primarily offers services ranging from sales of new scientific and analytical instruments to the repair and maintenance of spectrometers and analyzers, sample preparation equipment, and integration of automation. Other products include the supply of laboratory items, parts and consumables, and even software for laboratory information management systems (LIMS). SPECTROMART strives to be customer-centric and to improve processes and skills as a fundamental part of its vision for long-term progress and sustainability. The founders of SPECTROMART are confident in delivering high-quality products to clients, along with technical support and application services, from UAE and gradually expanding into other Middle Eastern countries.

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